📋 SUMMARY

Research published in Science Translational Medicine (2025) used 3D Petri Dish® cardiac organoids to discover that PIEZO1 downregulation causes TKI cardiotoxicity.

🔬Cardiovascular

PIEZO1 Downregulation Mediates Tyrosine Kinase Inhibitor Cardiotoxicity

Science Translational Medicine · 2025 · Manhas et al.

Cite: Manhas et al. Science Translational Medicine (2025).

🔑 Key Findings

  • TKIs cause cardiotoxicity by downregulating PIEZO1
  • PIEZO1 loss disrupts calcium handling
  • Cardiac organoids accurately model drug-induced heart damage
  • PIEZO1 agonists may prevent cardiotoxicity

🧫 3D Petri Dish® Application

3D Petri Dish® micro-molds enabled consistent cardiac organoid generation for drug screening.

FAQs

What is PIEZO1?
A mechanosensitive ion channel that helps heart cells respond to forces.
Why do TKIs cause heart problems?
TKIs downregulate PIEZO1, disrupting cardiac function.