📋 SUMMARY

Research published in Cell Stem Cell (2021) used iPSC-derived 3D Petri Dish® cardiac spheroids to reveal how LMNA mutations disrupt chromatin organization.

🔬Cardiovascular

LMNA Mutations Disrupt Chromatin Architecture in Dilated Cardiomyopathy

Cell Stem Cell · 2021 · Shah et al.

Cite: Shah et al. Cell Stem Cell (2021).

🔑 Key Findings

  • LMNA mutations cause chromatin reorganization
  • Disrupted nuclear architecture leads to aberrant gene expression
  • 3D cardiac spheroids accurately model laminopathy
  • Potential therapeutic targets identified

🧫 3D Petri Dish® Application

3D Petri Dish® enabled formation of iPSC-derived cardiac spheroids that recapitulate disease.

FAQs

What is LMNA cardiomyopathy?
A genetic heart disease from lamin A/C mutations.
How does chromatin disruption cause disease?
Abnormal chromatin leads to misexpression of cardiac genes.