📋 Summary
This study by Daley, M.C. et al was published in Toxicological Sciences, 2024. It utilized Microtissues 3D Petri Dish® micro-molds for 3D cell culture, contributing to advances in cardiac research.
In vitro to in vivo extrapolation from three-dimensional hiPSC- derived cardiac
Daley, M.C. et al. In vitro to in vivo extrapolation from three-dimensional hiPSC- derived cardiac microtissues and physiologically based pharmacokinetic modeling to inform next generation arrhythmia risk assessment. Toxicological Sciences 2024
Research Overview
This publication by Daley, M.C. et al represents important research in the field of cardiac. Published in Toxicological Sciences, 2024, this work employed 3D Petri Dish® micro-mold technology from Microtissues to create uniform, reproducible 3D microtissues for their experimental studies.
🔬 3D Culture Approach
- Utilized Microtissues 3D Petri Dish® micro-molds for reproducible 3D spheroid formation
- Enabled physiologically relevant cell-cell interactions in a controlled 3D environment
- Supported the study of complex biological processes that cannot be replicated in traditional 2D culture
How 3D Petri Dish® Enabled This Research
🟢 3D Petri Dish® Application
The researchers chose Microtissues 3D Petri Dish® micro-molds to generate uniform 3D microtissues, enabling more physiologically relevant experimental conditions compared to traditional 2D cultures.
- Non-adhesive hydrogel micro-molds promoted self-assembly of cells into 3D spheroids
- Uniform microtissue size ensured experimental reproducibility
- Compatible with standard cell culture workflows and imaging techniques
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FAQs
3D Petri Dish® micro-molds are non-adhesive hydrogel molds that allow cells to self-assemble into uniform, reproducible 3D microtissues (spheroids). They are compatible with standard cell culture protocols and support a wide range of cell types and applications.
3D cell culture provides a more physiologically relevant environment compared to traditional 2D culture. Cells in 3D form natural cell-cell interactions, develop gradients of nutrients and oxygen, and better mimic in vivo tissue architecture — all critical for cardiac studies.