📋 SUMMARY

Research published in Science Advances (2020) used 3D Petri Dish® spheroids to reveal a triangular correlation between cancer aggressiveness, nanoparticle uptake, and cell deformability.

🔬Oncology

Triangular Correlation Between Cancer Aggressiveness, Particle Uptake, and Cell Deformability

Science Advances · 2020 · Brill-Karniely et al.

Cite: Brill-Karniely et al. Science Advances (2020).

🔑 Key Findings

  • Cancer aggressiveness correlates with particle uptake and deformability
  • More aggressive cancers show increased nanoparticle internalization
  • Cell membrane mechanics predict tumor invasion potential
  • 3D spheroid models essential for studying these relationships

🧫 3D Petri Dish® Application

3D Petri Dish® enabled formation of uniform tumor spheroids for systematic study.

FAQs

What is the triangular correlation?
More aggressive cancers have softer cells that take up more nanoparticles.
How can this help treatment?
Understanding particle uptake improves targeted drug delivery.